Endocrine Abstracts

Background: The first-line treatment in acromegaly is transsphenoidal adenomectomy of GH-secreting pituitary tumor. Pathologic evaluation of postoperative tissue is an essential part of patient’s assessment.Aim: The aim of this study was to analyse pathologic characteristics of pituitary tumors in patients with acromegaly.Patients and methods: One hundred twenty patients with acromegaly after at least one pituitary surgery tre...

Background: Transsphenoidal adenomectomy of GH-secreting pituitary tumour is a first-line treatment of acromegaly. Pharmacological treatment is recommended if surgery did not lead to disease remission. Pathological assessment of postoperative tissue provides clinicians with valuable information on the disease course.Aim: The aim of this study was to assess whether clinical, imaging, and pathological characteristics can predict surgical remission and resp...

Pituitary tumor is a rare endocrine disorder. In the majority of cases, they are secreting prolactin and/or GH. Pituitary metastatic tumors are localized more often in the nervous than adenomatous hypophysis. Lung, breast and large intestine cancers metastases are found in the pituitary in the most cases. They cause hypopituitarism and local complications. The most often complications found are an optic nerve chiasm pressure or infiltration with a visual field loss, cavernous ...

Nelson’s syndrome (NS) is a rare clinical syndrome of an enlarging, aggresive corticotroph pituitary adenoma that can occur following bilateral adrenalectomy performed in the treatment of CD.The aim of this work is the evaluation of the early and long-term results of the microsurgery in a single surgeon’s series of patients with NSDuring the period from January 2000 to December 2005 - ten patients with NS have been operat...

Introduction: Ectopic Cushing’s syndrome (ECS) is a rare endocrine condition caused by corticotrophin (ACTH) hypersecretion of nonpituitary neoplasms. Thymic neuroendocrine tumours (NETs) account for about 5-10% of ECS cases, typically with aggressive clinical course.Case Report: A 31-year-old previously healthy female presented to the emergency department with a 3-week history of fatigue, muscle weakness, headaches and generalized swelling. Physica...

Isolated sarcoidosis of the hypothalamic-pituitary system is a very rare form of neurosarcoidosis. It usually leads to secondary damage to endocrine function, resulting in hypopituitarism and diabetes insipidus. A 32-year-old male patient with progressive deterioration of his general condition, weakness, polyuria, dizziness and visual field disturbances was admitted to the Department of Endocrinology for the diagnosis of a tumor in the hypothalamic-pituitary region. MRI showed...

Background: The treatment of choice in prolactinomas are dopamine agonists, with surgery reserved for cases refractory to or poorly tolerant of pharmacotherapy. Little is known on the associations between clinical, neuroradiological and pathological features influencing the efficacy of transphenoidal surgery.The Aim: To evaluate clinical, neuroradiological and neuropathological aspects of surgically treated prolactinomas in women, with a particular empha...

Introduction: Atypical pituitary adenomas are often characterized by rapid growth and massive invasion of the surrounding structures. Usually, they are associated with poor prognosis and high recurrence rate due to resistance to conventional therapies. When surgery and radiation are ineffective, alternative therapies remain the last line treatment. Lately, a novel chemotherapy with capecitabine and temozolomide was proposed as a highly effective and extending the life of the p...

Introduction: The empty sella syndrome (ESS) is defined as the penetration of the subarachnoid space into intrasellar region. In ESS pituitary hormonal function is usually normal, but several, mostly subtle, hormonal abnormalities have been also reported. The coexistence of Cushing’s disease and primary empty sella is very rare.Objective: The presentation of an exceptional case of a patient with Cushing’s disease associated with primary empty s...

Introduction: Crooke’s cells are normal corticotrophs with cytoplasmic accumulation of cytokeratin filaments in response to glucocorticoids excess. Crooke’s cell corticotropinomas are the unique cause of Cushing’s disease. Nearly all of them are invasive macroadenomas, generally aggressive, refractory to conventional therapy, with high recurrence rate.Aim of the study was to present a case study of a patient with Cushing’s disease cau...